Which Crusher? Wesley had his mom, and we know Beverly was close with her grandmother, but I don't remember her parents being mentioned either way. As for Neelix: he lost his family in the war, but I get the feeling he was a young adult by then.
I believe Beverly's parents were said to have died when she was a kid in "Sub Rosa". I could be wrong about Neelix.
My original point (which was admittedly unclear) was that the Star Trek orphans thing is overblown, and it's more about tragic deaths, as others have said. The minutiae of who counts as an orphan is not that interesting to me because rigid boxes in general are silly, and wasn't really my point.
Main characters with formative tragedies in their past (before their first appearance):
James Kirk - survivor of Tarsus IV, survivor of
Farragut disaster
Leonard McCoy - had father euthanized but then cure developed shortly after
Nyota Uhura - *NEW* parents and brother died while she was young
Will Riker - mother died in his youth; abandoned by his father; survivor of
Pegasus incident
Deanna Troi - father died in her childhood; had really obnoxious mother
Beverly Crusher - parents died in her youth; husband died young
Tasha Yar - orphaned; survived rape gangs
Worf - orphaned
Wesley Crusher - dad died in his childhood
Ben Sisko - wife killed by the Borg (technically this was depicted in his first appearance, but in a prologue sequence)
Kira Nerys - mother disappeared, likely as sex slave to Dukat; father killed by Cardassians; many, many friends died during her time in Resistance; she killed people herself as part of that effort
Odo - made misstep that cost innocent Bajorans their lives
Julian Bashir - genetically reengineered (without his consent)
Quark - father dead
Ezri Tigan - personality/mind rearranged when took unexpected symbiont transplanted
Jake Sisko - mother killed by the Borg
Kathryn Janeway - father died in her youth
Neelix - family killed in war crime in his youth
Seven - assimilated by the Borg as a child
Jonathan Archer - father died "unfulfilled"
T'Pol - father died; murdered a guy (don't really remember the plot; too lazy to look up)
Michael Burnham - parents killed as a child; in first appearance had a mother figure killed in part due to her own mistake
Saru - parents culled as part of species erroneous conditioning by slaver race
Ash Tyler - murdered and "reborn" as part of a Klingon
Adira - orphan? boyfriend died and they took his symbiont into themself, causing amnesia
Becket Mariner - friend eaten by her boyfriend
Dal R'El - orphan? enslaved
Jankom Pog - enslaved
Zero - force removed from people; enslaved
Rok-Tahk - enslaved
