^ Some interesting ideas here. In my version, I swapped out the Dominion for the Borg, but if we keep them, making Beverly the Female Changeling is genius. You get to get rid of her and experience the "performance" in a very different, meaty, way.
Deanna, in this version, reclaims the Guinan role she lost with the addition of Goldberg. She might have been fascinating as the empathic barkeep. Though I'll miss the Counselor in Ops idea hehehe...maybe we could sneak a command bench in their somewhere
It's also nice to honor O'Brien this way. Though, would we make him a lieutenant?
Riker would be the permanent Defiant skipper, a commander in the rank structure like Sisko was while initially commanding the ship, and like in real life where often it's an officer lower than a captain commanding a ship and called "captain." La Forge there is also good, as you need to populate the ship with more crew. Maybe he's chief engineer there,
Shelby's the first officer,
Lavelle's the pilot, others?
Taurik, Duffy, Lefler, Argyle, Gomez...
I wouldn't want to keep
Q a human though. I think
Pulaski and
Selar could replace Crusher on the station and or the Defiant. He could have some other role in the series. Either similar to that on TNG, or a new one with he Prophets. No pat-wraiths though in this series. The closest I'd allow is
Nagilum being a baddie from the alternate dimension of the wormhole who envelopes the whole station/ship/wormhole and experiments on everyone as he explores our universe. He'd be pandemonium on the Promenade.