When Coulson came to May after telling Skye about the female SHIELD agent dropping her off, I thought for a moment that we were about to get the revelation that May was Skye's mother. But I guess the agent/possible mother was the corpse in the photo.
I think that, with the appearance of Jasper Sitwell (whose name I keep mixing up with Farley Stillwell, the guy who created the Scorpion), the show has now featured every SHIELD comics character who's appeared in the movies and isn't technically a superhero (like Black Widow or Hawkeye). Plus we get a comics character who hasn't been in the movies, Victoria Hand.