(of course he will just as Coulson will escape.. they're main characters after all).
You do remember this is a Whedon show, right...?
It's not a "Joss" Whedon show but his brother.. Joss is just giving main direction to the show to have it tie in well with the larger Marvel movie universe.
It's also too early in the show to kill off main cast characters, especially Coulson without whom the entire show would tank pretty fast.
So i don't expect them to kill of anyone in the first 2 seasons at least, if ever.I don't know if they have total creative control or if Disney is making sure they don't endanger the product by making controversial creative decisions (i doubt that if Firefly would have been a Disney show that Wash would have been killed off for example).
They don't shy away from a bit of controversy such as Couslon making some hard choices that are unusual for prime time entertainment shows but i don't know if that would extend to the main cast (though if Sky would be chosen to die i'd not lose sleep at all over it).