Yeah, saves can kinda be a pain at times. I hate it when games don't let me pause when I want (even during a cut scene) or save when I want. That said, once you're into the first town you can do a lot more free roaming and only a few talks trigger missions. You can kinda put them off a bit but I do recommend doing Hosea's missions first. It's the only way to get a fence unlocked and upgrade camp and you def. want to upgrade camp to unlock crafting and fast travel.
Well I have another problem. I have to help someone with the dynamite for the train robberie, but the moment I want to pick it up the game crashes. anyone familiare with the bug?