Hey, I saw this on the Daystrom Institute Reddit.

Well I won't give the same answer.
Show everyone on the verge of break through faster than light travel technologies. The Federation has been growing benamite crystals for decades and is nearly ready to release its first artificial batch; the Trill, Bajorans, and Gorn are working out the final bits of artificial wormhole creation; Klingons have been working on Iconian gates; the Vulcans are working on the code named thing, maybe some sort of slingshot like Voyager; no one else is sharing if they already have anything better than warp.
Despite amazing non-Temporal post Temporal War technologies still existing they have fallen by the wayside in favor of lower power, simpler, more efficient technologies as peak dilithium becomes ever worse. Ships are already looking a lot like the 32nd century and have taken a long fall from the power and sophistication of post Temporal War ships, even stripped of their temporal technologies.
Ok, so more tech. Make beaming the way everyone gets around in solar systems. Everything ignores trasnwarp beaming so I guess I will too, but subspace beaming is a thing and that has a range of a lightyear or so. That should allow star clusters to have beaming networks. There should be a real push to enhancing transporter range and efficiency to supplant ships in local star regions using repeaters. But like semaphore it should require extremely peaceful regions since sabotage is easy, though not catastrophic. Just bounce the beam back to the origin.
Shuttles should already be exclusively runabouts since beaming should be just about perfectly predictable and safe to the extent that it has relegated turbolifts and ship based transporters to backup systems.
Replicators should go full ship size. I've always wanted that to pop up and the closest we have so far is the shuttle replicator in Prodigy. A good start. The switch to programmable matter should actually be a crutch of sorts due to the loss of megareplicators, with its original use as an automatic, decentralized hull patching technology. Turns out replicating vats of programmable matter is lower in power cost than replicating the ship whole.