When I was in high school I had several run-ins with this moron who took exception to having to attend the same school with a kid in a wheelchair. He and two of his friends decided to make my life a living hell. At first, I just tried to ignore them, but after a while, their behavior started to grate on me. One day, they decided they were gonna slap me around, and when they tried, they were surprised when I fought back. The instigator tried to punch me in the face, but, sitting down, I was able to duck that with no trouble, and when was regaining his balance in mid-swing, I slammed into him with my wheelchair. The impact wasn't too powerful, but it did knock him down. One of his buddies was surprised I was able to defend myself, and at the same time, decided to switch sides, and he ended up helping me chase his friends off. The other two never bullied me again, and he and I were friends for several years after that.
In my high school, there was some bullying, but even the bullies left physically and mentally challenged kids alone. I once saw one of the biggest assholes in school beat the crap out of someone else who tossed his drink at a classmate of mine that had Downs, didn't even know him.