Ok. I'll take you on Orphalesion.
She was prejudiced. Every time she called Data, Daataah (with the unforgivable British accent, Data corrected her and she didn't care). But her prejudice created a way, over 30 years later, for Data/Lore and Moriarty to come back. We'll have to wait and watch where that goes when Picard S3 airs, but I've always loved TNG's version of Moriarty best (more even than Sherlock or House).
I think the problem is this: Data, being such a well rounded and complex character (next only to Spock, if that) poses a central challenge for us hoomans: we either treat him too much as a human (Picard, Measure of a Man) or not enough (Bruce Maddox, same episode). The point that gets lost is that Data isn't human, but, for his sentience, has every claim to every right that humans claim for themselves.
Into this picture, I feel, Pulaski inserts herself magnificently, neither too much to the left nor to the right. She's neither all-understanding Picard nor all-consuming Maddox. She simply asks, if a "computer" can really solve a problem beyond its programming. And thereafter the story unfolds brilliantly.
I think Pulaski, and much later, Picard, struggle with this central question: Data exposes the limits of humans, but are there limits to Data as well? Emotions, friendships, daughters...?
I love Data.