Well, that was a hell of a thing. I was expecting resolution to the Android vs Zhat Vash situation, but there were more definite endings than I was expecting. The rest is wide open, and I'm more convinced than ever that the show is going to be a "Picard's greatest hits tour."
I'm betting we'll see a Klingon arc (probably with Worf), a Cardassian arc (possibly with Madred, maybe with Ro, if Michelle Forbes wants to come back for this). I want more with the Romulan survivors, the average ones, the people struggling to survive, not just the Tal Shiar and Qowat Milat outliers. If we get back to them at all, seeing Sela wouldn't go amiss. I imagine Guinan and Q might show up together to give that storyline some definition and resolution after all these years. And we might see Traveler!Wesley if they want to go there.
All of this is speculation of course, but if I was expecting the next season to involve loose plot threads from this one at all, that's kind of out the window.