Jeeze I found it hard enough already, almost ran out of Deuterium a couple times
So did I on the first playthrough.. but then I realized I was just gathering resources willy nilly without paying attention to how much I can store.
On the second and third run, I was just stocking up resources as I needed them.
I was careful with Deuterium (to get it when I needed it), and more generous with gathering Duranium.
That way you can manage better until you can make the cargo bays to increase storage capacity.