The big question is can the show work without Niles. Fraser show would not be what it was without Niles.
Exactly. Those two helped to make it what it was. Same with the rest of the cast.
I guess we'll just have to see what kind of chemistry Frasier has with Niles son. Part of the dynamic is supposed to be that Frasier gets along with and has more in common with his nephew that he does his son.