During a recent conversation on Twitter James Gunn said that he doesn't consider the Marvel Television stuff like Agents of S.H.I.E.L.D. canon for the MCU. It sounds this was just his personal opinion, so it might not necessarily be Marvel's official stance.
Another stupid thing James Gunn has said on Twitter...
Endgame pretty heavily contradicts the AoS time travel story.
How so?
Until Marvel (and by that, I mean Feige or the other higher-ups) indicates otherwise, I consider it all canon: the ABC shows, the Netflix shows, Runaways and Cloak and Dagger.
Helstrom?