Some people wanted to lend credence to the idea that the series takes place after TUC. Praxis is from TUC and Amargosa is from Generations, the next movie.
It's a little flimsy.
I don't think that the series will take place during the Praxis disaster, but it will possibility start during that time period and continue on through the century, maybe beyond, going through multiple ships, stations, crews, heros, and villians, kind of like Roots and How the West Was Won type thing.
Praxis and Amargosa has nothing to do with each other, Praxis was already distroyed at lease a year or more before the Nexus energy ribbon came, But Praxis and the Romulan star going nova could have something to do with each other. That if both were deliberately, instead of a accident, (Praxis) and Nature (Romulan Star) ?
If that the cast? Then whom ever distroyed both Praxis and the Romulan star, are the same people, and they are enemy of both the Klingons and Romulans, and they are on the opposite side of both Klingons and Romulans empire from the Federation; And maybe would be the cost of the Klingons asking the Federation for a peace treaty with them and the Federation. And cause the Romulans is also ememies of the same emeny that the Klingons are ememies of, that the Federation ask them to join in. Which will allow them to build a star base that will house Crews and their families from all three powers, a center base for their starships, which they themself will have their own crew and will be sent out on their own mission and the series will not just ficture episodes of the starbase, but will ficture episodes of missions that those starships go own. Which could be episodes of missions that different starships are sent on, and those episodes will focus on that starship mission, regardless if it's Klingons, Romulans or Federation.