I really consider Supernatural to be the spiritual successor to The X-Files. 2 people going places and investigating strange goings on is the focus of the show really, but the story arc is more tightly done than the x-files.
It's very much just supernatural goings-on with the occasional horror episode, there is a lot of humour to the show so even in the scariest episodes there's usually something to lighten the tension and make you laugh.
The episodes range from horror to creepy to out and out laughs. Definitely worth checking out if you're an X-Files fan I think.
I've never been one to enjoy slasher films, or gorefests.
Nothing against them, just never GOT them.
Supernatural is one of my favorite series though for its incorporation of folklore, mythology, legend, & wit.
One of my favorite series to read is The Dresden Files by Jim Butcher, and I've always considered Supernatural about as close to Dresden as we've seen on TV thus far. (and that includes the Syfy Series based on but not much resembling the Dresden books)
If you've ever seen the film Constantine w/ Keanu Reeves, you get an idea of how the real world can co-exist right alongside the weirdness and most people never know of it, rationalize it away, or just plain can't accept what they've seen.
Supernatural, is definitely a show for fans of Buffy & Angel, but again, with a darker twist than either.
Both of these comments were really helpful - thanks for posting. Very encouraging as well since I enjoy The X-Files, Buffy/Angel and Dresden (although I did not read the Dresden books - only saw the series).
You guys have convinced me to try out Supernatural - I have borrowed the S1 DVD set and will start this week.

This might have been covered earlier, but how many seasons are there so far? And how is the show doing? Is it expected to continue for a while or what?