Okay serious crazy predictions:
Worf is a cripple, in a spaceage wheelchair. Something bad happened during his stint as Captain of the Enterprise.
Geordi has been sad and lonely since Data died, but doing important starship design things. He's married to a holo of Leah Brahms and everyone just accepts it without thought as to how creepy the implications are.
Beverly is Captain of the Pasteur or running Starfleet medical or somesuch. She has whole tests named after her now.
Riker and Troi will be back Starfleet full-time as if season one never happened, and their daughter won't be mentioned. Riker is an Admiral now.
Sela will show up at some point.
As to Worf, more likely something happened during his second stint as Ambassador to Qo'nos. He and Martok had way too much blood wine before going on one of their Targ hunts.