As far as I'm concerned, seasons one through five fit into the mcu with no problem whatsoever. Seasons six and seven take place on Earth 617, along with Cloak and Dagger and Runaways.
I still think season 6 is reconcilable with a post-Snap world where people are just still in denial and trying not to talk about it. The focus of the season is narrow enough that there's nothing to rule it out. And season 7 is in the past anyway.
I see no continuity issue with C&D, and the only issue with Runaways (ignoring the alternate Tina Minoru in Dr. Strange, who isn't named on camera anyway) is that its third season contradicts Endgame's theory of time travel. But then, so do the X-Men movies, and apparently we're now supposed to consider them part of the same multiverse.