Hugh wasn't 'de-assimilated' in "I, Borg". He was gaining his sense of self identity. Janeway and the others got assimilated but it was shrugged off completely, whereas before it was a source of massive PTSD for Picard and Seven's entire character journey was getting back the humanity that was stolen from her as a child.
And Hugh's next appearance clearly showed there were issues with his gaining individuality, because he described feeling so lost that he and the other Borg felt the need to be controlled again. Never mind whatever anger he held after the failed experiments Lore did on them.
So no, Hugh's situation did not neuter it. (I'll agree that it gave hope for other assimilated people and that might be construed as neutering. But that wasn't the point of "I, Borg"... being able to look past the face of your enemy and see a victim was the point. "UNIMATRIX ZERO" purposefully made assimilation something to just shrug off because it was a part of the plan. It completely undermined what Picard and Seven went through, not to mention the colony in "UNITY", the trio in "SURVIVAL INSTINCT", Icheb, or the other kids.)