It does; one nice thing about SF is that it's got a pretty sizable downtown, with some pretty high skyscrapers (much higher, say, than the pint-sized ones of Boston, or the non-existent ones of DC), but also has lots of other, very varied neighborhoods. Also, you've got the legitimately still-gritty and grungy Oakland just across the Bay. Fincher got some great mileage out of our Financial District in The Game, for instance.
Sure, Chicago could probably also work, but while it's got some great downtown areas, as seen in Transformers DOTM/TDK, I haven't really gotten the sense that its non-downtown neighborhoods are all that special or distinctive.
Sure, Chicago could probably also work, but while it's got some great downtown areas, as seen in Transformers DOTM/TDK, I haven't really gotten the sense that its non-downtown neighborhoods are all that special or distinctive.