I think this was probably the end of the road for Picard and Data. Definitely the end of them all together as a group. If Legacy actually becomes a thing, then I imagine we'll see Crusher, Riker, Geordi, and Troi again in live action at least once more. Those are the actors I've seen the most say they'd love to do more appearances and/or have been hyping up the spinoff idea. Plus, narrative wise given who would likely be on Legacy, they make the most sense for cameos. Worf is a question mark for me, but I'd lean maybe/yes. Live action aside, I could see all of them popping up on LD and Prodigy as well.