Why would it be different? You're just changing the hormones and changing your genes wouldn't radically re-sculpt your body, it wouldn't really do what hormones don't already do. The human body (and likely any other humanoid species in Trek) is already pretty good at dealing with different hormones. Once the hormone balance shifts in a person, genes just express themselves based on that hormone. A trans person on hormones goes through the puberty of their gender. The only advances that would make sense would be some way to fully change the reproductive organs, you could do showing a pregnant trans female character.