If we're taking about something that's intended to be an ongoing series, then I'd like mostly standalone/episodic, but throw in some serialized elements. Every week would be new adventure and story, but the decisions the characters made and the relationships formed in the previous episode(s) would carryover to the next episode and beyond. It's not just a blank canvas every episode. Imagine if in season 4 of TNG, Picard dealt with some sort of PTSD throughout the whole season in reference to the Borg. We got a little bit of that in 'Family', but what if it lasted several episodes? The episodes and stories would still be pretty much the same, but every once in awhile you get a glimpse of Picard's struggle. (Note - Just using this has a hypothetical example and totally not criticizing TNG - it was a product of its time and had a formula it had to adhere to.) I'm not an "The Orville is better than STD!!" guy, but The Orville to an extent does do this, blend standalone with serialized elements.
I don't have anything against serialization (I love Game of Thrones) - but one of the greatest things about Star Trek, and one of the key factors why it's been alive for so long IMHO, is that you can literally take almost any episode of TOS or TNG, regardless what season it's from, and watch it whenever you want. You want to watch The Inner Light? Go for it. Got 55 minutes to kill? Balance of Terror sounds good. With serialization, there's a shelf life. You're not going to just randomly start watching an episode of Game of Thrones or Breaking Bad... or Discovery.
Now, if we're talking a limited-run/mini series, obviously you'll want to serialize it. That's a little different. A contained 6-9 episode arc with a certain, definite ending is easier to consume than an ongoing serialized TV show that kind of tapers off in the later seasons.
There, hopefully I didn't ramble too much.