It makes as much sense as anything Data does.

A certain kind of TNG fan hates that joke (cos there's no sex in Star Trek, dammit!), but I think it's underrated. The basis of it is actually in those key DS9 scenes (usually involving Quark) in which the Federation's lofty principles are treated with ... a certain irony; in this case the Trekker ideal that women of the future are too pure to be aware of their own anatomy. Then Data tries to make conversation and makes the usual social faux pas, and the capper is that we are forced to contemplate Worf's boobs, which I imagine would be lobster-like, and very firm. No, that's not really the joke, but mocking Worf is always fun, and
that's the joke.