One of mine, and you might see this more as a sort of "filling the gaps of canon" kinda thing, is to just deem overpowered things as "unstable." It works like a charm - watch:
Why do they still use starships after both Scotty (transwarp beaming) and the Dominion invent basically range-less transport methods? Simple: because the methods are unstable.
Where's the conflict if everybody has industrial replicators? Well, they're not ideal replacements for genuine handiwork - after all, they're unstable.
And why doesn't everybody use augment blood if it's a miracle cure for death? Because it's risky! Do you have any idea what that blood could do to you? Kirk got lucky - that crap's unstable!
It's a bit like that teleport thing they do in Harry Potter and Fantastic Beasts - apparently it's a risky method of travel that you're supposed to avoid doing, but our main characters with their plot armor can do it as much as they like. And I'm surprisingly cool with that.
Why do they still use starships after both Scotty (transwarp beaming) and the Dominion invent basically range-less transport methods? Simple: because the methods are unstable.
Where's the conflict if everybody has industrial replicators? Well, they're not ideal replacements for genuine handiwork - after all, they're unstable.
And why doesn't everybody use augment blood if it's a miracle cure for death? Because it's risky! Do you have any idea what that blood could do to you? Kirk got lucky - that crap's unstable!
It's a bit like that teleport thing they do in Harry Potter and Fantastic Beasts - apparently it's a risky method of travel that you're supposed to avoid doing, but our main characters with their plot armor can do it as much as they like. And I'm surprisingly cool with that.