With holodeck safety protocols off, a 24th century GTA could kill you.
Yes but you would not turn them off now would you?
If your holodeck was connected to the internet, maybe some nice hacker would turn them off for you.
That would be my biggest fear. Since hackers don't give a fuck about ruining other peoples' lives anyway, what would stop them from messing with safety protocols in a game, if they thought their tech was strong enough to avoid detection?
Don't like that noob in a holodeck version of Call of Duty? A hacker could just turn off the safety protocols and kill the noob. Of course, once the hacker was caught, he could be tried for murder, and not just cyber-terrorism.
But then, I think all hackers should be burned at the stake, drawn and quartered, put on the rack, shot, hung, and beheaded!
Unless you work for the government or law enforcement to use your skills to track down illicit hackers, then you are no good to society as a hacker.
But enough of my hatred toward such wastes of oxygen.
A game or games I would love to see translated to holodeck: Fallout 3, Fallout New Vegas, or the Elder Scrolls games starting with Oblivion.

Open world, variety of weapons and bad guys...NPC's to interact with... and hell, even being able to take your friends into the game and have them be a part of your group as you wander the wastes of Washington, D.C., New Vegas, or Tamriel, playing however you want to play. Do you want to do good and right the wrongs? Or have you always longed to play the bad guy?