Now I am not talking about the shuttle. I could see that but as slightly modified cargo ship. I am talking about an actual star ship.
Do you think they will use any ships designs from star trek, Stargate, etc.
I think a future ship will be pencil-shaped or cylindrical. Keeping it long and thin is good because it will need to go through a lot of space while crashing into as few particles as possible. For this reason it will also have a thick and strong particle-shield up front, and since this shield will be heavy and expensive, it cant be to wide. This will also partly be because stuff that collides with the front-shield (the particles, dust, gas and so on) will deccelerate it.
A third reason for why the future space-ship will be cylindrical and long is that the living-space up front will want to distance itself from the engine, that will be hot and produce radioactivity, same with the powerplant. There wille be radio-blocking plating between this stuff and the rest, unless the fuel-tanks can block out most of it.
So Im pretty certain that a future ship will be shaped like a long cylinder. A elevator, a ladder, or both will go through it, and the floors will be arranged so that the floors faces the engine. This is also where the downpull will go during acceleration, so if we have gravity-plating by then we can shut it of during periods of acceleration and deceleration.
But it might also be that a future ship is donut-shaped and rotates around itself 2001 space-odyssey style. These kinds of ship will have a cylinder with food and water in the midle of the donut, and then the engine will be attached below it.