Fanboy misogynists would have you believe that the reason the movie didn't do better than it did at the box office was because of the lead characters were all played by women actors. The four women stars are among the most accomplished comedic actors working today. Movies have trouble drawing paying customers for all sorts of reasons as this movie did, but of all the issues it had, the lead actors weren't a part of the problem.
"Ghostbusters" failed because it was a bad movie,sexism and yet another needless reboot all combined. Sometimes things fail for multiple reasons. That doesn't even factor in the terrible adds and the horrible CGI being used in those adds were the ghosts looked very lame. Would have helped also if they at least set it in the same universe as the first movies and had the cameo's be from the characters people already loved.
Jason