Hmm, there would have been less constraints because of what we already know will happen in the future. In a post Voyager timeframe, preferably a good chunk later, the writers would have had a chance to be more creative and shake up the "Trek formula" a bit more IMHO.
I think that the show made plenty of episodes that had nothing to do with Trek history and made up new history as they went. Not that the Expanse episodes were bad (I think they were good episodes, and an appropriate response to 9/11) but really, nothing like that ever happened in any previous show's future history.
Edit: They could have just as easily had the attackers be the Romulans instead of the Xindi and told the story of the Earth-Romulan war.
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