I am watching Guardians of the Galaxy II right now, and I think: For the Orville to work for me, it needs to become less Star Trek, and more Guardians of the Galaxy. The comedy in the dialogue, situational comedy and 20th century pop culture refences work so much better in Guardians. It gels perfectly. "Star Trek: Beyond" already went into the direction.
Are you a fan of Farscape? That was basically Farscape.