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The Big Thing About X-Men Origins

The old Handbook of the Marvel Universe said something like "strips of adamantium were fused to Logan's bones in an unknown fashion." Their wording made it pretty clear that the entire surface of the bone was not supposed to be covered in adamantium, only enough to give it reinforcement (and it seems likely some of the smaller bones might not have adamantium at all).

This was before Weapon X, of course, but it does give you some idea how he was pictured back in the 1980s.

It also says that the presence of adamantium does not interfere with his body's ability to generate white cells, but it doesn't say why. This was before his healing factor was shown as so ridiculously overpowered, so the writer probably didn't make that connection. But a couple of issues of Uncanny X-Men, in the mid-230s or so, did have Wolvie losing his healing factor and his immune system started to suffer as a result.

Frankly, I've always wondered more about Bullseye. He's supposed to have gone through the same adamantium bonding process, and he doesn't have a healing factor.
 
He doesn't have an adamantium skeleton like Logan, his is just some adamantium put onto some parts of his spine.
 
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