A is for the Alpha Quadrant, where most of the known powers and species of the galaxy are located.
B is for Bob Wesley.
C is for the Cardies as their enemies refer to them.
D is for Denobulans.
E is for Elaan of Troyius.
F is for Farragut. The U.S.S. Farragut.
G is for Gorn territorial claims to outposts and worlds along the Federation border.
H is for Holodeck recreations of people you know. So you can mess with them.
I is for Inter-species procreation.
J is for James T. Kirk, one of the most legendary and accomplished officers in the entire history of Starfleet. He literally saved Earth on at least several different occasions during his career.
K is for Klingon bastards.
L is for Leah Susan Brahms, Geordi's crush
M is for Montgomery Scott. Chief Engineer of the USS Enterprise; NCC-1701. The reason why Starfleet engineers have the reputation of being miracle workers.
N is for Nausicaans.
O is for the Ogla, a type of kazon.
P is for the Praetor, the ruler of the Romulan Star Empire who presided over their Senate.
Q is for Q, Picard's favorite foil.
R is for Rom, who became the grand Nagus
S is for the Steamrunner-class Federation starship of the late 24th century.
T is for T'Pol's bum.
U is for Unimatrix zero where seven was a woman instead of an automaton.
V is for V'Ger, once a late 20th century Earth space probe that fell into a black hole and emerged near a planet of hyperadvanced and sentient machine life forms.