The Irumodic Syndrome was confusing to me. It was implied in All Good Things to be a degenerative disease but here it just seemed like something that would just kill you at any time.
That's one of the many things that bugged me too, Irumodic Syndrome was meant to be space Alzheimers, it wasn't meant to be a ticking time bomb that just would go off suddenly like an aneurysm. So that bit annoyed me.