Yes, because "alien cultures" in Star Trek are nothing more than imitations of foibles and customs found in human culture, but don't require the experience or research of people other than those you already know in order to write about.
Shapeshifting? Human master of disguise. Maybe he can't turn himself into a realistic elephant or a vase like Odo might be able to, but he can blend into any social environment with makeup, clothes, languages, and mannerisms.
The Founders are unique in one way: in that they have an expansive empire nearly covering a quarter of the galaxy and for awhile even more, all so they can revel in their natural isolationism and xenophobia. Its sort of like a man afraid of fire burning every forest down so he won't ever experience forest fires again. Others expand their civilization for resources, for cultural expansion, for honor, because they view their ideals as just and need to expand them to others. The Dominion expands to be left alone.
Essentially, any weird thing an alien can do literally and naturally, a human can do with tech/superpowers and/or metaphorically.
In reality though, most likely humans would encounter civilizations thousands of years more advanced, possibly with even more enhanced intelligence It's nice to imagine a Star Trek or Project Hail Mary universe where the nearby aliens are at about the same level of technological prowess and have mostly the same brain power, but its not likely.
Think how well it's worked out for every human culture that ran into another significantly more advanced. Not well. But Star Trek wouldn't work well as a series about a silent galaxy of hidden species all practicing Dark Forest theory.
