LD does nothing Trek hasn't done before, that's one of its defining traits... and I guess I just don't really care about continuity in Trek enough to have a significant "headcanon" at this point. It has always been a mongrel, seat-of-the-pants creation, and Lower Decks continues that tradition (emphasized through its tongue-in-cheek simultaneous reverence for and roasting of the slapped-together universe it lives in).
There was a time when it drove me nuts that Trek production seemed to treat continuity as an enemy instead of a resource; more recently I've come to the realization that embracing the improvised and pieced-together nature of Trek is embracing the soul of Trek, and that every production takes its own particular approach to that. LD's comedic approach is no less valid than any other. I don't have to precisely triangulate which "canon" it's in or to have a "headcanon" for it beyond recognizing that all the pieces of Trek are just aggregate "headcanon" of various production teams grafting their own interpretations onto something that consisted from the beginning of exactly those types of grafts. I voted "Mostly" but I really should have voted "Completely."
(There are sci-fi universes that have continuity and consistent worldbuilding built into them, which is cool and is why I love The Expanse. But I'm over expecting Trek ever to achieve that or even aspire to it. Its DNA is just different, and is likely to stay that way.)