We did have Miranda Kadohata in the TNG Relaunch, and I think she left the Enterprise shortly after Destiny to work closer to her family.
Right, and another character I remembered after posting this question was David Gold of the da Vinci (although all of his children (and most of his grandchildren) are grown up by the time we get to see him). But as I was writing it, I was thinking about characters such as Kirk (who was for all intents and purposes an absentee father), Picard (who was childless for almost 50 years while serving as Captain of the Starzager and two Enterprises before finally starting a family), Sisko (who was raising his son as a single father on a starbase rather than a starship), and Janeway and Archer (neither of whom have any children...yet). We do hear a little about how Geordi was raised the child of two Starfleet officers (his father is a science officer who took more ground and starbase postings than shipboard ones, while his mother was a command officer and it was implied that at least one of them was home while the other was on a ship), and these days we have Tom Paris and B'Elanna raising their children on Voyager, Riker and Troi are raising Tasha on Titan, and Picard and Crusher raising Rene on the Enterprise, but with Owen Paris in particular, I'm curious how not having his family with him affects him and his career.