Cage era style Phasers that now have much more detail than the TOS version and seem more advanced, leaving to real reason to drop the Kelvin inspired "flip effect" for each setting down to the single crystal of TOS.
The rifles are now entirely different. Communicators on the show are custom wraps around old jailbroken iPhone 4S's so they now have interactive touch screens.
As does everything else, all buttons and old circuits and now proper touch screens and futuristic interiors, so no opening them to do old fashioned soldering in overalls.
No episode where the viewscreen acts weird or has to be reset, windows for various episodes to look out and see ships/people/planets. Information relayed by Spock is now shown on the screen itself.
Pulse phasers all the time so none of the dramatic leaving the beam on for ages to melt something, just pummelling it from obit.
Site to site transports that happen safely and quickly so no episode with a locked door, security teams beaming in to stop Riley and Khan in those episodes.
Better biometrics to seal off access so no drunken crew members getting away with shutting down engines, smarter computers that might lock people out and take the ship over entirely if enough of the crew are comprimised. Constant psych eval programming to stop listening to insane Captains when they start to go loopy.
Brigs with smart controls and stronger forcefield so Charlie making a wall disappear just makes it extend the forcefield to enclose it again. Instant ones from TNG popping up around intruders.
All Klingon and Romulan ships look different. Romulan ships with brow ridge crew, shaven head slaves and Reman workers in the dangerous sections.
The location lock system for the sporedrive along allows far better long range scanning, Sarek seeing light coming from a system that had only started emitting it hundreds of lightyears away means way better FTL sensors.
Shuttlebays have forcefields, like the TMP ones (that massive hanger was open all the time in TMP with no decompression, so they had it by 2271) so it's not much of a stretch to just give the 1701 it too, so no decompression wait times. People standing in the bay as shuttles of the new design come and go, cargo kept in there.
No bubble shield effect, it's more like Kelvin/Nemesis skin tight ones now. So all battles look different. Complete wit h every shot exploding against the hull as they do now for no reason.
No sudden swinging around at warp, keeping to linear movement and no fights a warp but to be honest, that's more in keeping with literally anything post TOS.
The Cloud Creature can no longer entire the ventillation system, being held by the ship itself in a valve somewhere and forcing it back out. Or never getting through shields at all. Why there was a direct access from external vents on the ship to everyones rooms was worrying enough.
No burn outs of the dilithium circuits, so that episode never happens. Tractor beams are used more and visibly appear.
The Mirror Universe Spock notices something about Kirk that prompts him to access the ships database, finds references to the Prime universe complete with diagram of the new Defiant refit from DSC, and refers to him as being from the "Defiant's universe" and mentions major upsets to the Empire always accompany the presence of people from it. Lines about Evil Kirk rising to the greatness of Sato, or the fall from power of Georgiou.
The entire courtroom episode, just scanning the interior of the Enterprise or checking the access logs, would have solved that one anyway. But now the computer would have made it easier to find either.
That new Earth at the edge of the solar system complete with the same level of sunlight as Earth would have and 80,000 person superstarbase would have to factor into it. Starbase 1 now being there instead of Berengaria VII, means Spock was stationed in the Sol system, so no dragons.
Starfleet has about 200 years of data about Vulcans, so most of Spocks storys change considerably. As does his medical care, and his anticipation of his Pon Farr, taking leave that easily.
A lot more aliens on the Enterprise, helping with varous situations and away missions. Andorians being a Federation member state, not green marauders.
Replicators with added programmed attitude. No food cubes.
Off duty personnel out of uniform and in those black shirts.
Romulan Commander is a lesbian now. The Enterprise becomes a statue on Romulus, the crew are executed. Whoops.