Actually, Marvin the Martian (though he didn't have a name yet) made his first appearance in the 1948 cartoon Haredevil Hare, starring Bugs Bunny. I think an animated Marvin in a contemporary live-action universe could work, but he needs a strong character like Bugs or Daffy as a foil.You can't really have Marvin without Duck Dodgers IMHO.
Yeah, I'm only familiar with Marvin the Martian in Duck Dodgers in the 24½th Century. It's interesting that the character goes back as far as 1948. As you say, Bugs would work just as well as a foil. The main problem with Marvin the Martian as a main character might be that, apart from the eyes, he doesn't have a face. I believe his proposed antagonist was Santa Claus.

http://en.wikipedia.org/wiki/Marvin_the_Martian#Planned_film
I wonder how much money WB spent on that turkey.
I said The Golden Compass instead of His Dark Materials because, as great as TSK and TAS are, I'm not exactly burning to see film adaptations of 'em. Don't get me wrong, I'd love to, and I'd love to make them myself, but I'd also be totally satisfied with one really good, complete TGC. 