I always wished that after DS9 premiered, the Enterprise-D would be sent on a long-term exploration mission in the Gamma Quadrant, and TNG could thereby get back to its original intention of being about a ship exploring the unknown, rather than just spending most of its time on diplomatic and political and rescue missions to known planets. It would've allowed for periodic crossovers whenever the E-D had to check back in at DS9 for repair, resupply, etc.
That would have been awesome.
This is one of the reasons I love Titan so much, because that's *exactly* the purpose of the series, out exploring the unknown.
Minor side note while on this tangent (and certainly not a nitpick): why not have Titan explore the Gamma Quadrant, which is a largely untapped but "known" piece of the Trek mythos, instead of starting out exploring the Orion Arm?