I love StarTrek DS9 was the best IMO, Loved Battle Star, Star Gate is ok but I hated Babylon 5 with a Passion.
How would someone like this do with Fire Fly?
Uh, I don't think that any of those shows are really comparable with Firefly. The show is basically a gritty western set in space with bits of comedy thrown in.
If you're really looking for comparisons I would ask whether you've seen the Coen brothers' True Grit. Firefly is True Grit... with spaceships!

But why don't you simply watch it? It's only 14 episodes anyway.