It was more frustrating that Uhura wasn't ever given command. She was command trained (wore a yellow uniform early on) but they drafted in the assistant chief engineer instead. Not surprising in the sixties but annoying that this was never rectified later, including in the new film where 17-year old Ensign Chekov is given command instead! Ouch.
I think Uhura was in command in a TAS episode. But that was after all male crewmembers were... incapacitated.