While the Defiant was designed as a Borg-buster, it's clearly not capable of soloing a Cube. The idea was that there'd be squadrons of them. We see the Defiant struggle to best the Lakota one-on-one, and that's just an Excelsior-class (albeit one upgraded with enhanced phasers and quantum torpedoes); it also only rarely. While very powerful for her size, the Defiant is TINY – it's doubtful indeed whether it could go toe-to-toe with a Sovereign-class or Galaxy-class. The Enterprise-D might still be the most powerful ship in the whole museum.
Eh, I'm not so sure.
USS VOY was released into active service about a year or so after the D was half destroyed and the saucer crash landed on Veridian III.
VOY sported state of the art technology of its time, and the crew did so many adjustments and mods in the DQ (and the ship got tactical updates from SF in the last season too via the data stream too which the crew implemented)... not to mention the future technologies (though those were seemingly removed from the ship).
So, I would imagine the Voyager was probably on par with (or extremely close to) the upgraded Galaxy class ships (post Dominion War) in terms of power output, weapons and shields - just smaller.
If I was in Picard's shoes, I would have taken the Enterprise-D, Voyager and the Defiant. All 3 would be coming from roughly the same era, have comparable tactical systems, and could be run with skeleton crew and automation fairly easily.
Seven and Shaw (had he survived) could have used the Voyager... and Worf could have been placed on the Defiant.
The Defiant may be tiny but it was also stated to be overpowered for its size... it was shaking itself apart during field testing due to the SIF not being able to keep the ship together reliably past Warp 9 without shuffling extra power into the SIF system - but otherwise, seemed to have been quite powerful.
The Defiant's phaser output was doubled with a certain method (Riker's transporter clone explained it to Kira in one of the DS9 episodes)... and it stands to reason similar mods could be done on the Galaxy and Intrepid to increase phaser power output yields due to modular nature of SF ships (in case they were not already as powerful - and I suspect they were - so the VOY and ENT-D could have gained even more destructive power output for phasers at least).
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