Two separate remake options I'd consider--
1. Rather than being about the Robinson family characters who left Earth, I'd make the series about their grown-up grandchildren (i.e. two generations after Will/Penny/Judy, presumably after having met improbable space humans), still in the now-old Jupiter 2 and increasingly questioning the family obsession with finding the area of space that includes Alpha Centuries and/or Earth.
2. A reimagining of the original characters, but in this version they aren't pioneers; they're a normal (if Jetsons-level) family living in one of the thousands of mobile space habitats orbiting Earth, until some weird event on Earth they had nothing to do with unexpectedly displaces their habitat to a far region of the galaxy. After plot events in the pilot lead them to obtaining a stardrive, though, they rise to the occasion, determined to find their way home, however long it takes.
In neither version does anyone ever say either "Danger, Will Robinson!" or "Oh, the pain, the pain."
1. Rather than being about the Robinson family characters who left Earth, I'd make the series about their grown-up grandchildren (i.e. two generations after Will/Penny/Judy, presumably after having met improbable space humans), still in the now-old Jupiter 2 and increasingly questioning the family obsession with finding the area of space that includes Alpha Centuries and/or Earth.
2. A reimagining of the original characters, but in this version they aren't pioneers; they're a normal (if Jetsons-level) family living in one of the thousands of mobile space habitats orbiting Earth, until some weird event on Earth they had nothing to do with unexpectedly displaces their habitat to a far region of the galaxy. After plot events in the pilot lead them to obtaining a stardrive, though, they rise to the occasion, determined to find their way home, however long it takes.
In neither version does anyone ever say either "Danger, Will Robinson!" or "Oh, the pain, the pain."