Someone else's ears are keener than mine, when it comes to this question, but in Nemesis, Sir Patrick Stewart's voice sounds noticeably husky, gravelly. He could still project his "Picard Voice," though, like during his speech, at the wedding. Particularly when he got past the "all what I've done with My LIfe" part and started directing it towards his friends. He sounded pretty good, mostly.
For the rest of the movie, it sounds like he's been gargling with Draino. I don't know at what point before that movie his voice went. But it was damned depressing. He looked like he was a hundred and two, besides. If you listen to him in the TNG series saying shit like, "Warp 9 - any heading - Engage!" it's larger than Life. Very commanding and authoritative. Listening to him croaking his lines in Nemesis, frankly ... it broke my heart.