* Kira and Odo were openly hostile to Quark, to the point where by the last few seasons Kira was just nasty to him.
Everyone mistrusted Quark, he was engaged in a lot of criminal activity, whilst his misogynistic manner would also have rubbed people like Kira up the wrong way. The only time people were actually hostile to him was when he became a weapons dealer, which offended Starfleet sensibilities. Despite his nefarious manner, he did have a heart and often did the right things (granted, sometimes for profit), but when he was left destitute after the Ferengi Commerce Authority revoked his "business license" Sisko, Odo, Dax, Bashir and a huge number of the stations crew and residents supported him with furniture and supplies to get him back on his feet.
* You always thought Odo had some kind of affection for Quark, but it didn't turn out that way. Odo was entirely self-serving and self-absorbed. He didn't hide his contempt for his human comrades. He sentenced an entire colony of people to non-existence for his selfish "love" of Kira. He was perpetually in a foul mood.
Odo was gruff but lovable. His harsh exterior was due to his development at the hands of scientists and being a plaything for Cardassians, but he had a heart that he protected--as evident by the torch he carried for Kira. In a lot of ways, Odo is really a moody teenager, given he's still young for a Changeling, and as such lacks emotional intelligence to voice what he feels. As for him and Quark, one is a lawman the other is a criminal. They have some great back and forth, both with a great deal of unspoken respect for each other. When Odo leaves the station, he won't give Quark a "goodbye" but turns his back, but Quark wouldn't expect anything else and states "that man loves me, it was written all over his back".
* Kira was just full of hate and anger. I prayed someone would just phaser her.
How would you be if your homeworld and species were under the tyrannical and oppressive rule of another race for decades? Your planet and people were ravaged and abused, forcing you to rebel and fight from the time you were barely a teenager and forced to do horrible things that will haunt you for years? Only to get your freedom and have your "leaders" invite another big powerful organisation to "help"--which the Cardassians said they were there to do when they first arrived. Kira's arc over the series sees her grow from the angry terrorist to a seasoned leader, she learns from Sisko, Dax and the others around her to become a better person.
*The Bajorans were supposed to be this great civilization, but they are contemptuous, self-serving and whiny. I got so sick of the whole "occupation". Here's a thought. You don't want to be occupied? Be strong and able to defend yourselves. When did they start to work well with StarFleet?
They were in an isolated region of the quadrant, where their culture was driven by their caste system and heavily influenced by their religion. Before the Cardassians arrived they were a peaceful people, who were unprepared for the savageness that the Cardassians brought. You might want to go and ask the population of the Czech Republic, Slovakia, Austria, Denmark, France, etc. why they didn't do anything to stop themselves being occupied in the 1930s and why they didn't defend themselves.
* And the doctor is IMO, is the absolute worst character in all of ST. The writers couldn't figure out what to do with him, like so many of these characters. Genetically engineered? Indeed. O'Brien's "friend". I get tired of his whining "KAHmaaandah" to the point I just fast-forward his scenes.
Bashir was a character I didn't like in the beginning, but he does seem like the kind of upstart, smug, pretentious, overly-entitled person that you're not meant to like much in the beginning, but as you get to know him you see his strengths. His friendship with O'Brien is one of the most honest and endearing of the franchise, which was built on over time not just immediately "hey, we're senior officers on the same ship, let's be besties".
* Everyone was mistrustful of Garak.
Wouldn't you? He is someone who doesn't let anyone know that much about him in the beginning, though takes a shine to Bashir and develops a good back and forth with him. As the series progresses then all the other characters have their time with him, and he becomes an integral part of the community whose dark and shady past plays vital roles during the Dominion War--if not for him the Federation and Klingons would've lost without the Romulans getting involved.
* Quark treated his nephew and hs brother like crap.
As is Ferengi culture. They are his employees, so he can use them as he wants in order to advance his own profits. But he does truly love them, often through his actions more than anything else (such as how he tends to and defends Nog on AR-558) but also says as much when Rom is made Grand Nagus.
* O'Brien was a tepid character. He was nasty to Quark too. His "friendship" with the doctor was so hopelessly contrived...
O'Brien is the "everyman", which is why #ObrienMustSuffer.
* The lounge singer was one of the stupidest plot threads since Data's stand up comedy, which thankfully lasted only one episode.
Vic wasn't a highlight. He had moments when he was a good addition (such as helping Nog with his recovery) but more often than not he was a grating addition--but then again all holograms become tedious.
* Even Worf was disgusted by the doctor, accusing him of being an immature child that played with toys, which he was. Worf had little love for anyone except the Captain and Dax.
Worf was looking out for Dax, not believing that Bashir was a suitable match for her (also coming off as more than a little jealous of her choice). Bashir and O'Brien were "playing" with a model set of the Alamo, and seeing as how many adults these days collect or make models then it's hardly such a childish thing.