Well you can have an uplifting and optimistic viewpoint in a terrible situation, Take another series, Stargate (Sg1, Atlantis.. not so much universe) It was optimistic, cracking jokes, even when the Earth was in mortal danger. Voyager could have done the same in that, yes were 75 years or more away from family, friends.. All we have is this ship. Morale would have been a big problem, but if it showed everybody coming together, supporting each other. They showed that they were tight knit in the show.
They could have done some stuff that showed them generally optimistic, mostly happy, but some people going in to depression, maybe could have dealt with a Suicide of a crew member that maybe his or her best friend was killed by the kazon, and they just went down a dark path, have the crew try to help, but in the end, they take there own life. and then show what the fallout would be. That would have been a good moral story on depression, suicide, and what to do to help.
Maybe have a group of 10 or so crewman decide, we want off this nightmare ship with its Dictator captain!! and they find a nice planet, and then we deal with the fall out from that, maybe even show them on the planet change there mind after some mishap, and then show them trying to catch up to voyager.