How about a Star Trek fighting game ala Tekken or Street Fighter. T'Pol does Suus Mahna, Worf does his Bat'leth stuff, Kirk does Kirk Fu, Riker does Anbo-jyutsu, etc. Fights are preceded by one-liners, like Picard says "Engage!" or Deanna says "I sense hostility!". And when the fight's over, the game goes "Finish him!", and you press a secret button combo to unleash your Picard Speech on your helpless opponent. Fatality!