Controversial opinion: I think the Starfleet Academy concept is fundamentally flawed, and part of the reason they've never been able to make it work over the past 30-ish years that it has been thrown around as a possible movie/TV series is that it requires contrived circumstances to put a bunch of cadets in the middle of big, dangerous compelling events.
It either has to center around a combination of:
1. Young teen CW drama stuff (i.e., love triangles, personal grudges, etc.), and the drama comes from the soap opera aspects.
2. Young cadets uncovering a conspiracy within Starfleet Academy or Starfleet as a whole.
3. Cadets being sent out to serve aboard starships and other posts (a la Nog aboard DS9), but at that point it becomes a more serious version of Lower Decks.
Moreover, what can you fundamentally do in the 32nd century that you can't in the 25th other than individual personal transporters, non-physically connected ship nacelles, and programmable matter? I could see a a sort of Andromeda-ish storyline of the Federation reestablishing contact with member worlds and rebuilding. I do hope they DON'T follow Discovery's model that every season needs to be about stopping some plot to destroy the galaxy/universe, and go more the Strange New Worlds route of individual episodes that might have bits and pieces that may build to something over a season.