There is a very good argument as to why a good deal of the hardware/plumbing should and needs to be hidden. Take into account current human spaceflight standards, where any mechanical systems that could potentially injury an astronaut, and doesn't need to accessed on a routine-mission basis, are concealed and covered.
These standards I would think would still be in effect, if not more stringent.
As far as accessibility, quick release panels would easily satisfy both requirements of safety and maintenance.
This Ryan Church layout seems to address safety standards to a degree, with the railings to keep personnel separated/protected from the equipment.
When I saw the brewery engineering on screen I couldn't help but keep saying to myself "No, No, No............"
Even
modern day cruise ships have a better safety standards than what appears to be in the NuEnterprise's Engineering.