From what I recall of the original trailer, the basic premise seems fairly insular and contained, so if there are or ever were any connections to any kind of larger established continuity it's likely to only really be in the form of the odd name drop and probably not anything directly connected with the actual plot of characters. If that's the case then in theory, any hypothetical switch from XMU to MCU, or excising entierly would simply be a matter of looping a few lines or maybe CG'ing over some production design ephemera, like a headline or whatever.
I'm only curious as to whether this is the case so far as it indicates how they're planning to introduce mutants into the MCU. It'd be kinda cool if they use this as a kind of backdoor to show by inference alone, either that they've always been there but in very small numbers, or it's a totally new phenomenon (possibly thanks to Wanda.)
