The most annoying sound in DS9...

[Farscape One]

I have to admit, Rom screaming in "NECESSARY EVIL" IS pretty bad.

 

[Herbert]

The sound of Quark

Fixed

 

[NCC-73515]

Rom making noise with the cutlery in anticipation of his breakfast

 

[Tenacity]

Sisko employing his barking "voice of command."

Every time I'm thinking "when will this be over?"

 

[FanST]

Definitely the Grand Nagus laughing