Harvey,
glad to hear that someone else thinks the way I do.

One of things I love about the novel series Vanguard (which I am just getting into) is that the cast of characters doesn't correspond to the usual department head dynamic that has been a Star Trek prerequisite. I don't think we needed an Operations officer, primary helmsman, or morale officer. I am not saying get rid of those characters, but it seemed like they needed to plug regular actors into predetermined roles on the ship, and that took precedence over creating an overall character dynamic. And there is nothing saying a guest star in season one couldn't become a regular in season two or three.
Or, if you insist on a large cast, follow the way of SGU or B5, where you may go a few episodes without seeing certain characters, as they are not important to the plot at hand.
And I love the idea of dragging out the Alpha Quadrant plotline for an entire season. Then getting lost in the Delta Quadrant is no longer the primary plot, but an extension of the adversary dynamic developed over the first season. A short first season (say ten to thirteen eps) would have been fine as well. It seems like SyFy, for all of its faults, does produce better seasons of its series by limited season length. Following this logic, Voyager could have had a half to full season back home at the end of the series as well. I think it would have served for a LOT of character resolution to not be rushed to tie everything up in ninety minutes. Then we wouldn't have been subjected to the ill-advised and painful Chakotay/Seven no-mance, Tuvok's magical disorder than minifested overnight, or the Doc's model/arm candy wife.
But going back to the secondary cast idea, it would have been nice to see more Maquis who didn't integrate quite so well throughout the series. Besides the ones who were traitors or eaten by alien dinosaurs, and killed off early, we don't see much in the way of Maquis. Crewman Gerron could easily have been the "apprentice" character that Icheb became. Perhaps Mariah Henley could have been a little more rebellious than wearing a red headband. Although I did like the scenes in S2 where B'Elanna is dressing down Hogan for being as hot headed as she was when the show began.